Clinical description for all disease except Ebola virus disease
The clinical course varies among the VHFs, but a typical case might experience a prodrome of fever, headache, myalgia, facial flushing, conjunctival suffusion and malaise that lasts 3-4 days, followed by worsening of these symptoms with prostration, evidence of capillary leak (non-dependent oedema, effusions), haemorrhage, shock and impaired consciousness. Low platelets, disseminated intravascular coagulopathy (DIC) and liver damage are common.

Additional clinical features that are relatively specific to the main VHFs include:

• haemorrhagic fever with renal syndrome: pulmonary infiltrate and respiratory failure
• hantavirus pulmonary syndrome: pulmonary infiltrate and respiratory failure
• Lassa fever: upper and lower respiratory tract symptoms, including exudative pharyngitis. Eighth cranial nerve deafness in 25 percent of survivors
• Marburg, Ebola: pharyngitis, diarrhoea and vomiting, maculopapular rash

Ebola virus disease
Follow this link for the clinical description contained in the case definitions for Ebola virus disease